One thing I miss from New Vegas is the ability to kill absolutely anyone you meet and the quests would adapt. Its pretty impossible to actually fail a mission in Skyrim any other way than dying. I want to be know through Tamriel that I raised Whiterun to the ground for too many "wet dog" comments.
I haven't tried so far, but they promised you can kill most of the quest givers and their relatives will take over being that quest giver. Well, I wondered why so many random NPCs are immortal, like barmen and half of the mages guild. thx to Destroyer I yesterday found a nice bug, Sanguine does not disapear after his quest and stays right in a dungeon with loads of NPCs that keep attacking him whenever you enter the zone.
Atleast the Talmor are always in for a quick "Hello Sir, do you like praying to Talos?" "Sure!" "Oh, then I'll just start attacking you with my shitty magic!" w00kie summons a daedra lord and a sexy fire atronach, takes out a soul eating bow, shoots three arrows and moves on. (after raping the slave they brought with them)
What is worse, the portal to that magic spot of Sanguine can be accessed from underneath the blob and it blocks a chest and a strongbox with loot from that archmage. Fucking. Cherries.
werewolf is only good as a panic button at the beggining, like in a one on one vs a sudden hagraven with fireballs.